at 0.25 my appetite is gone entirely, did anyone go down rather than up
#tirzepatide 2025-11-18
Tuesday52 messages12 participantstimes are UTC
Highlights from this day
- assay_not_purity — right so i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more 22:46
- assay_not_purity — at 15 the GI came back for me, so my easier profile claim only applies below that, ask me again in a month 23:03
- split_shipment — is the 40 vial the common one or do people use 10 23:12
follow up im at 0.25 and thinking about 0.5, did anyone gain anything from that step
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switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
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the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
slightly off topic but did going from 12 semaglutide to 5 of this feel like a step down for anyone
at 1 my appetite went completely and i dropped back a step, eating nothing isnt a win
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did anybody switch back to semaglutide after trying this
the sweet spot thing is survivorship, the people it worked for stayed and said so
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whats the plateau pattern here, same as semaglutide or different
plateaued at 6 weeks the same way i did on semaglutide, so i doubt its compound specific
folklore probably
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from
15 is the top
anyone stopped at 10 and stayed there for months
the two compounds arent interchangeable week for week even if the effect ends up similar
titrate slow
is 7.5 really the sweet spot or is that just channel folklore
is there a reason to titrate slower than the four week schedule
i went to 15 and came back to 10, more suppression wasnt more useful for me
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
[edited]there is no clean conversion between the two, anyone giving you a ratio is guessing
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switched last year
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, ymmv
£55 for a 10 vial is roughly what ive paid for the last year, thats one data point
right so i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)😂1📈11
did anyone go past 15 and was there any point to it
why does everyone talk about 7.5 and not 10
5 did nothing
the trials titrated every four weeks to a target, most people here stop at whatever works
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
sorry to jump in is SURMOUNT-OSA the sleep apnoea one
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GIP plus GLP-1
at 15 the GI came back for me, so my easier profile claim only applies below that, ask me again in a month
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SURMOUNT is weight
start low anyway
is the 40 vial the common one or do people use 10
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🎉1😂10📈5
how many weeks at 7.5 before you knew it was enough
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)📈1
anyone tracked whether the GI difference held at the top doses
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no clean conversion
10 was enough
the sweet spot argument is really about effect per side effect, not a magic number, ill dig out the number
the sweet spot thing is survivorship, the people it worked for stayed and said so
held 10 for 18 months and lost 20kg over that stretch, slow and boring and fine, someone check my working
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, i have it written down somewhere
the GI difference held for me right up to 15, which isnt what a couple of people here found
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does switching from semaglutide need a gap or do you just start
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easier gi for me
how did people handle the 2.5 to 5 jump
40 units of a 4 solution is a lot of volume and i check that one twice every single time
Batch lookup SG-1177: 7 independent reports on file, earliest 2025-04-02.
dual agonist, GIP as well as GLP-1, thats the whole difference in one line