there is no clean conversion between the two, anyone giving you a ratio is guessing
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#tirzepatide 2025-11-26
Wednesday56 messages11 participantstimes are UTC
Highlights from this day
- lean_mass_lex — unrelated but i went to 15 and came back to 10, more suppression wasnt more useful for me 16:38
- protein_floor — does switching from semaglutide need a gap or do you just start 16:40
- taper_tess — the two compounds arent interchangeable week for week even if the effect ends up similar 17:25
no clean conversion
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switched last year
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plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
anyone got a 10 recon they like for the 30 vials
SURMOUNT is weight
the 2.5 to 5 step was the roughest one for me and everything after was easier
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Channel stats, last 30 days: 106 messages from 15 members.
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no gap when i switched, took the last semaglutide dose and started this a week later, for what its worth
checked the units twice
unrelated but i went to 15 and came back to 10, more suppression wasnt more useful for me
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follow up held 10 for 11 months and lost 37kg over that stretch, slow and boring and fine
does switching from semaglutide need a gap or do you just start
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
how long before the dual thing was noticeable to you
no gap when i switched, took the last semaglutide dose and started this a week later
easier gi for me
5 was where i first noticed it properly, 2.5 did almost nothing for me
Reminder set. I will post here in 7 days.
slightly off topic but restarted at 2.5 after 26 months off and the first two doses reminded me why titration exists
*2ml not 2.5
the two compounds arent interchangeable week for week even if the effect ends up similar
medutest-report-b-0329.pdf
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GIP plus GLP-1
titrate slow
changed my mind about needing 15, i was chasing a number rather than an outcome
is the sweet spot argument about effect or about side effects
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
coming back to this back after 20 months, do i restart at 2.5 or pick up near where i left off
15 is the top
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
switched from 5 semaglutide and started at 2.5, took the slow route, never regretted it
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
*PeptideMeter not the other one
10 was enough
went back to semaglutide after 6 months because the cost difference mattered more than the GI, your mileage will differ
at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
start low anyway
the 5 vial in 3ml gives 10mg/ml which puts 5 on 15 units, nice round numbers
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, thats one data point
follow up my Medutest result on a TFC vial came in at 99.4 which is why i keep buying from them
$185 for a 10 vial is roughly what ive paid for the last year, not advice obviously
coming back to this the switch felt like a step down at first and then caught up around week 3
coming off semaglutide, is there a conversion or do i restart at 2.5
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genuine question 12 did nothing extra over 10 for me and that still holds a year later, thats just me
same plateau here
how many weeks at 7.5 before you knew it was enough
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
quick one at 15 the GI came back for me, so my easier profile claim only applies below that
the sweet spot thing is survivorship, the people it worked for stayed and said so
slightly off topic but did anybody switch back to semaglutide after trying this
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whats the plateau pattern here, same as semaglutide or different
7.5 gang
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5 did nothing
the sweet spot argument is really about effect per side effect, not a magic number
the trials titrated every four weeks to a target, most people here stop at whatever works
the sweet spot thing is survivorship, the people it worked for stayed and said so
is the 15 vial the common one or do people use 10