#tirzepatide 2025-12-01

Monday19 messages5 participantstimes are UTC

Highlights from this day

two_three_lifts — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ill dig out the number 22:32
two_three_lifts — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 22:42
two_three_lifts — plateaued at 7 weeks the same way i did on semaglutide, so i doubt its compound specific 23:04
two_three_lifts — went back to semaglutide after 10 months because the cost difference mattered more than the GI, someone check my working 23:08
dublin_dose — no gap when i switched, took the last semaglutide dose and started this a week later 23:12

titrate slow

no clean conversion

folklore probably

the trials titrated every four weeks to a target, most people here stop at whatever works

easier gi for me

there is no clean conversion between the two, anyone giving you a ratio is guessing

back after 23 months, do i restart at 2.5 or pick up near where i left off

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ill dig out the number

💀3👀15👍9

im at 1.7 and thinking about 10, did anyone gain anything from that step

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

🤝17💀17

is SURMOUNT-OSA the sleep apnoea one

follow up the 2.5 to 5 step was the roughest one for me and everything after was easier, still working it out

checked the units twice

👍16🤝3

7.5 gang

👀13🔥1

plateaued at 7 weeks the same way i did on semaglutide, so i doubt its compound specific

🤝8🙏2

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

went back to semaglutide after 10 months because the cost difference mattered more than the GI, someone check my working

held 10 for 13 months and lost 15kg over that stretch, slow and boring and fine

no gap when i switched, took the last semaglutide dose and started this a week later

❤️12🎉5📈8