i log everything and my appetite curve looks flatter across the week than my semaglutide log did
#tirzepatide 2025-12-12
Friday37 messages9 participantstimes are UTC
Highlights from this day
- amber_vial — no gap when i switched, took the last semaglutide dose and started this a week later 14:05
- question_queue — 12 did nothing extra over 10 for me and that still holds a year later 14:45
- lisbon_lot — at 15 the GI came back for me, so my easier profile claim only applies below that, i think 16:24
- lisbon_lot — the sweet spot argument is really about effect per side effect, not a magic number 16:35
- lisbon_lot — did anyone go past 15 and was there any point to it 16:53
does the appetite effect feel different or just stronger
titrate slow
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
no gap when i switched, took the last semaglutide dose and started this a week later
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at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win, we shall see
plateaued at 7 weeks the same way i did on semaglutide, so i doubt its compound specific
how did people handle the 2.5 to 5 jump
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
12 did nothing extra over 10 for me and that still holds a year later
Batch lookup G-0641: 9 independent reports on file, earliest 2025-10-31.
40 units of a 4 solution is a lot of volume and i check that one twice every single time, take that with a pinch of salt
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restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
i went to 15 and came back to 10, more suppression wasnt more useful for me
i sat at 7.5 for 24 months and never needed more, which is where the folklore comes from
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
7.5 gang
anyone got a 2 recon they like for the 40 vials
at 15 the GI came back for me, so my easier profile claim only applies below that, i think
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update on the earlier thing SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, ymmv
the sweet spot argument is really about effect per side effect, not a magic number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
changed my mind about needing 15, i was chasing a number rather than an outcome, not advice obviously
did anyone go past 15 and was there any point to it
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checked the units twice
no clean conversion
the switch felt like a step down at first and then caught up around week 4
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the 30 vial in 2.5ml gives 2.5mg/ml which puts 1.7 on 20 units, nice round numbers, not advice obviously
update on the earlier thing is the 20 vial the common one or do people use 15
my Janoshik result on a MKM vial came in at 98.1 which is why i keep buying from them
coming back to this licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, thats just me
unrelated but the trials titrated every four weeks to a target, most people here stop at whatever works
anyone tracked whether the GI difference held at the top doses
if youre coming off semaglutide the honest answer is start low and find out, theres no table, i could be wrong
€185 for a 2 vial is roughly what ive paid for the last year
start low anyway
dual agonist, GIP as well as GLP-1, thats the whole difference in one line