start low anyway
#tirzepatide 2026-01-02
Friday21 messages4 participantstimes are UTC
Highlights from this day
- coa_or_cope — €185 for a 10 vial is roughly what ive paid for the last year 18:14
- courier_vs_post — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted there is no clean conversion between the two, anyone giving you a ratio is… 18:57
- courier_vs_post — quick one the trials titrated every four weeks to a target, most people here stop at whatever works 19:02
- sulphur_burp — whats the plateau pattern here, same as semaglutide or different 19:46
follow up is 7.5 really the sweet spot or is that just channel folklore
€185 for a 10 vial is roughly what ive paid for the last year
🔥1⚠️6👀4
10 was enough
right so switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
unrelated but anyone stopped at 10 and stayed there for months
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
there is no clean conversion between the two, anyone giving you a ratio is guessing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
quick one the trials titrated every four weeks to a target, most people here stop at whatever works
no gap when i switched, took the last semaglutide dose and started this a week later
is the sweet spot argument about effect or about side effects
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
anyone tracked whether the GI difference held at the top doses
*VendorInvestigate not the other one
did going from 2.5 semaglutide to 5 of this feel like a step down for anyone
the GI difference held for me right up to 15, which isnt what a couple of people here found
whats the plateau pattern here, same as semaglutide or different
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)📉17
GIP plus GLP-1
the 30 vial in 2ml gives 5mg/ml which puts 5 on 30 units, nice round numbers
how did people handle the 2.5 to 5 jump
same plateau here