vialroom

#tirzepatide 2026-01-05

Monday23 messages3 participantstimes are UTC
Highlights from this day
  • turnaround_tam — i argued the sweet spot was nonsense and then spent 15 months at 7.5 not needing more 15:15
  • underfill_uma — ok so the two compounds arent interchangeable week for week even if the effect ends up similar 15:17
  • underfill_uma — the sweet spot argument is really about effect per side effect, not a magic number 15:52
  • electrolyte_eli — my PeptideMeter result on a GGPeps vial came in at 97.4 which is why i keep buying from them 16:52
  • turnaround_tam — how long before the dual thing was noticeable to you 17:23
TT

i argued the sweet spot was nonsense and then spent 15 months at 7.5 not needing more

Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.
UU

ok so the two compounds arent interchangeable week for week even if the effect ends up similar

⚠️13
UU

the sweet spot argument is really about effect per side effect, not a magic number

👀16

5 was where i first noticed it properly, 2.5 did almost nothing for me, we shall see

EE

my PeptideMeter result on a GGPeps vial came in at 97.4 which is why i keep buying from them

10 was enough

7.5 gang

is the 10 vial the common one or do people use 2

TT

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

how long before the dual thing was noticeable to you

🧊5

coming back to this anyone got a 2 recon they like for the 20 vials

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

follow up there is no clean conversion between the two, anyone giving you a ratio is guessing
i log everything and my appetite curve looks flatter across the week than my semaglutide log did

im at 0.25 and thinking about 2, did anyone gain anything from that step

SURMOUNT-1 versus SURPASS-2, which one was the weight trial