#tirzepatide 2026-01-17

my Janoshik result on a BCH vial came in at 97.4 which is why i keep buying from them, thats just me

there is no clean conversion between the two, anyone giving you a ratio is guessing

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

if youre coming off semaglutide the honest answer is start low and find out, theres no table

right so SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

does the appetite effect feel different or just stronger

i went to 15 and came back to 10, more suppression wasnt more useful for me
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

the 2.5 to 5 step was the roughest one for me and everything after was easier

i log everything and my appetite curve looks flatter across the week than my semaglutide log did

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

held 10 for 10 months and lost 37kg over that stretch, slow and boring and fine

im at 7.5 and thinking about 2.5, did anyone gain anything from that step

no gap when i switched, took the last semaglutide dose and started this a week later, your mileage will differ

switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it

start low anyway

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

im going to make the 7.5 argument again and people can shout at me

thats not an argument, thats an anecdote wearing a lab coat

brutal

there is something to it though. the SURMOUNT-1 dose response is not linear, 5 to 10 gained more than 10 to 15 did

correct, the curve flattens at the top. that is not the same as saying 7.5 equals 15 for you personally

and the flattening is on the group mean. individuals vary hugely in where their own curve flattens

i went 7.5 to 10 and nothing happened for six weeks. then 10 to 12.5 and it moved again. so my curve is not flat

thats one person

so is your 7.5 theory

both of you are right and neither of you is going to win this. keep it civil

the real argument for stopping early isnt efficacy, its sustainability

the dose you can actually stay on for two years beats the dose that makes you quit in month five

this is the only version of the 7.5 argument that survives contact with data

ill take it, thats basically what i meant

no it isnt, but ok

separate but related. does anyone else get appetite back on day 6 and 7

yes. very common at lower doses, much less common once youre higher

makes sense from the trough. weekly dosing means a peak and a trough, and at a lower dose the trough falls below your effective threshold

so its not psychological

probably not, no. and knowing about it makes it psychological as well, which is annoying

i split my dose to fix exactly that

of course you do

half monday half thursday. same weekly total. day 6 hunger gone

mechanistically defensible with a half-life around 5 days, you flatten the trough. there is no trial supporting it and you are doing twice the injections

twice the injections is not a side effect i care about

does splitting change total exposure

no. same weekly amount, same average. lower peak, higher trough. thats the trade

there is a longer version of this in #dosing-titration, worth reading before anyone reinvents it a fourth time

the sustainability point from earlier is the one that actually changed my mind, not the curve stuff

it changed mine too, about a year late