licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, not advice obviously
#tirzepatide 2026-02-01
Sunday55 messages11 participantstimes are UTC
Highlights from this day
- ten_of_ten — i log everything and my appetite curve looks flatter across the week than my semaglutide log did my Medutest result on a SSA vial came in at 96.8 which is why i keep… 20:12
- non_scale_win — my PeptideMeter result on a QYB vial came in at 99.4 which is why i keep buying from them, anyway 20:46
- fibre_first — how did people handle the 2.5 to 5 jump 21:50
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
same plateau here
checked the units twice
at 2 my appetite is gone entirely, did anyone go down rather than up
did anyone go past 15 and was there any point to it
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
i went to 15 and came back to 10, more suppression wasnt more useful for me
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did anybody switch back to semaglutide after trying this
does switching from semaglutide need a gap or do you just start
folklore probably
i argued the sweet spot was nonsense and then spent 12 months at 7.5 not needing more
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
my Medutest result on a SSA vial came in at 96.8 which is why i keep buying from them
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no gap when i switched, took the last semaglutide dose and started this a week later
the switch felt like a step down at first and then caught up around week 29
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, still working it out
did going from 10 semaglutide to 5 of this feel like a step down for anyone
start low anyway
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how long before the dual thing was noticeable to you
does the appetite effect feel different or just stronger
how many weeks at 7.5 before you knew it was enough
10 was enough
my PeptideMeter result on a QYB vial came in at 99.4 which is why i keep buying from them, anyway
40 units of a 5 solution is a lot of volume and i check that one twice every single time
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anyone tracked whether the GI difference held at the top doses
[edited]held 10 for 3 months and lost 21kg over that stretch, slow and boring and fine
12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the 2.5 to 5 step was the roughest one for me and everything after was easier
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
anyone stopped at 10 and stayed there for months
the GI difference held for me right up to 15, which isnt what a couple of people here found
*Janoshik not the other one
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
there is no clean conversion between the two, anyone giving you a ratio is guessing
at 15 the GI came back for me, so my easier profile claim only applies below that, n of 1 obviously
$185 for a 20 vial is roughly what ive paid for the last year
went back to semaglutide after 4 months because the cost difference mattered more than the GI
whats the top licensed dose, 15 or does it go higher
easier gi for me
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switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it, i could be wrong
GIP plus GLP-1
how did people handle the 2.5 to 5 jump
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did anyone find the GI easier than semaglutide at an equivalent effect
i sat at 7.5 for 1 months and never needed more, which is where the folklore comes from
no clean conversion
titrate slow
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does the GIP arm actually explain the easier nausea or is that hand waving
the two compounds arent interchangeable week for week even if the effect ends up similar
is 7.5 really the sweet spot or is that just channel folklore
SURMOUNT is weight
quick one anyone got a 10 recon they like for the 2 vials
whats the plateau pattern here, same as semaglutide or different
if youre coming off semaglutide the honest answer is start low and find out, theres no table, ymmv