5 was where i first noticed it properly, 2.5 did almost nothing for me, ymmv
#tirzepatide 2026-02-06
Friday31 messages8 participantstimes are UTC
Highlights from this day
- two_ml_two — the sweet spot argument is really about effect per side effect, not a magic number 22:50
- VialBot — On this day 2 years ago this channel logged 23 messages. 22:56
- power_cut_pia — at 15 the GI came back for me, so my easier profile claim only applies below that 23:45
- VialBot — Testing queue: 7 submissions open, 23 awaiting dispatch. 23:58
the sweet spot argument is really about effect per side effect, not a magic number
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the sweet spot thing is survivorship, the people it worked for stayed and said so
is there a reason to titrate slower than the four week schedule
On this day 2 years ago this channel logged 23 messages.
ok so i argued the sweet spot was nonsense and then spent 2 months at 7.5 not needing more
ok so is the sweet spot argument about effect or about side effects
titrate slow
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
while im here back after 6 months, do i restart at 2.5 or pick up near where i left off
no clean conversion
start low anyway
i went to 15 and came back to 10, more suppression wasnt more useful for me
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folklore probably
the 2 vial in 5ml gives 5mg/ml which puts 10 on 25 units, nice round numbers
there is no clean conversion between the two, anyone giving you a ratio is guessing, anyway
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
*2ml not 2.5
restarted at 2.5 after 10 months off and the first two doses reminded me why titration exists
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
at 5 my appetite is gone entirely, did anyone go down rather than up
went back to semaglutide after 4 months because the cost difference mattered more than the GI
[edited]how long before the dual thing was noticeable to you
sorry to jump in did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
7.5 gang
anyone tracked whether the GI difference held at the top doses
at 15 the GI came back for me, so my easier profile claim only applies below that
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coming off semaglutide, is there a conversion or do i restart at 2.5
12 did nothing extra over 10 for me and that still holds a year later, not advice obviously
Testing queue: 7 submissions open, 23 awaiting dispatch.