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#tirzepatide 2026-03-10

Tuesday40 messages10 participantstimes are UTC
Highlights from this day
  • net_peptide — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 14:39
  • seizure_letter — the 2.5 to 5 step was the roughest one for me and everything after was easier 15:36
  • net_peptide — coming back to this GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 17:15
DE

the sweet spot thing is survivorship, the people it worked for stayed and said so

😂8
NP

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

🤝12💀7🙏1
RS

the GI difference held for me right up to 15, which isnt what a couple of people here found

SL

while im here if youre coming off semaglutide the honest answer is start low and find out, theres no table

DE

restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists

NP

did anyone find the GI easier than semaglutide at an equivalent effect

🤝1⚠️3

coming back to this the two compounds arent interchangeable week for week even if the effect ends up similar

😂5🔥2

the trials titrated every four weeks to a target, most people here stop at whatever works

7.5 gang

how many weeks at 7.5 before you knew it was enough

switched last year

same plateau here

🎉4👀6

the 2.5 to 5 step was the roughest one for me and everything after was easier

🧊16👀3
LM

coming back to this i went to 15 and came back to 10, more suppression wasnt more useful for me

10 was enough

🔥12🤝5
NP

coming back to this GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)
👍9📈1
QH

40 units of a 5 solution is a lot of volume and i check that one twice every single time

📉7
SL

held 10 for 14 months and lost 47kg over that stretch, slow and boring and fine

PN

went back to semaglutide after 16 months because the cost difference mattered more than the GI

NP

for the archive is 7.5 really the sweet spot or is that just channel folklore

DE

back after 15 months, do i restart at 2.5 or pick up near where i left off

DE

anyone tracked whether the GI difference held at the top doses

GG

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

DE

changed my mind about needing 15, i was chasing a number rather than an outcome

janoshik-a-2418.pdf
2 pages · 870 KB · not retained in the public archive

does switching from semaglutide need a gap or do you just start