if youre coming off semaglutide the honest answer is start low and find out, theres no table
#tirzepatide 2026-03-13
Friday58 messages10 participantstimes are UTC
Highlights from this day
- sol_sends — the GI difference held for me right up to 15, which isnt what a couple of people here found 14:17
- sol_sends — €185 for a 2 vial is roughly what ive paid for the last year 14:23
- private_script_pri — whats the top licensed dose, 15 or does it go higher 15:07
- turnaround_tam — is the 40 vial the common one or do people use 2 15:55
- sol_sends — coming off semaglutide, is there a conversion or do i restart at 2.5 18:00
no gap when i switched, took the last semaglutide dose and started this a week later
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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the two compounds arent interchangeable week for week even if the effect ends up similar
anyone tracked whether the GI difference held at the top doses
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i sat at 7.5 for 24 months and never needed more, which is where the folklore comes from
the GI difference held for me right up to 15, which isnt what a couple of people here found
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🧪4
why does everyone talk about 7.5 and not 10
€185 for a 2 vial is roughly what ive paid for the last year
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SURMOUNT is weight
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, still working it out
plateaued at 22 weeks the same way i did on semaglutide, so i doubt its compound specific
changed my mind about needing 15, i was chasing a number rather than an outcome
ok so the switch felt like a step down at first and then caught up around week 29
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the 2.5 to 5 step was the roughest one for me and everything after was easier
i went to 15 and came back to 10, more suppression wasnt more useful for me
40 units of a 10 solution is a lot of volume and i check that one twice every single time, thats just me
turnaround_tamthe two compounds arent interchangeable week for week even if the effect ends up similar
whats the top licensed dose, 15 or does it go higher
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quick one switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
went back to semaglutide after 3 months because the cost difference mattered more than the GI
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
unrelated but the sweet spot argument is really about effect per side effect, not a magic number
while im here does the appetite effect feel different or just stronger
start low anyway
[edited]5 did nothing
at 0.25 my appetite is gone entirely, did anyone go down rather than up
unrelated but dual agonist, GIP as well as GLP-1, thats the whole difference in one line
[edited]slightly off topic but restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists
10 was enough
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
how long before the dual thing was noticeable to you
anyone got a 2 recon they like for the 10 vials
is the 40 vial the common one or do people use 2
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my PeptideMeter result on a SGN vial came in at 99 which is why i keep buying from them, someone check my working
7.5 gang
titrate slow
does the GIP arm actually explain the easier nausea or is that hand waving
5 was where i first noticed it properly, 2.5 did almost nothing for me
the trials titrated every four weeks to a target, most people here stop at whatever works
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*week 31 not week 4
checked the units twice
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the sweet spot thing is survivorship, the people it worked for stayed and said so
i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more
the 2 vial in 3ml gives 2mg/ml which puts 2.5 on 5 units, nice round numbers
there is no clean conversion between the two, anyone giving you a ratio is guessing
at 15 the GI came back for me, so my easier profile claim only applies below that
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15 is the top
GIP plus GLP-1
switched last year
same plateau here
12 did nothing extra over 10 for me and that still holds a year later
held 10 for 10 months and lost 43kg over that stretch, slow and boring and fine
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anyone stopped at 10 and stayed there for months
coming off semaglutide, is there a conversion or do i restart at 2.5
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is the sweet spot argument about effect or about side effects
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
is SURMOUNT-OSA the sleep apnoea one
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while im here did going from 5 semaglutide to 5 of this feel like a step down for anyone