how many weeks at 7.5 before you knew it was enough
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#tirzepatide 2026-04-02
Thursday62 messages12 participantstimes are UTC
Highlights from this day
- blind_submit — 12 did nothing extra over 10 for me and that still holds a year later 17:34
- coa_or_cope — ok so the sweet spot argument is really about effect per side effect, not a magic number, we shall see 17:55
- chlorhex — the trials titrated every four weeks to a target, most people here stop at whatever works 19:02
- two_eight_c — 40 units of a 10 solution is a lot of volume and i check that one twice every single time 20:07
- vacuum_vic — does the appetite effect feel different or just stronger 20:12
i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from
checked the units twice
restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists
[edited]whats the top licensed dose, 15 or does it go higher
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12 did nothing extra over 10 for me and that still holds a year later
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the 2 vial in 2.5ml gives 2mg/ml which puts 2.4 on 20 units, nice round numbers
does switching from semaglutide need a gap or do you just start
i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more
ok so the sweet spot argument is really about effect per side effect, not a magic number, we shall see
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the sweet spot thing is survivorship, the people it worked for stayed and said so
at 15 the GI came back for me, so my easier profile claim only applies below that
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anyone stopped at 10 and stayed there for months
switched last year
did anybody switch back to semaglutide after trying this
no gap when i switched, took the last semaglutide dose and started this a week later
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
£120 for a 20 vial is roughly what ive paid for the last year, n of 1 obviously
same plateau here
if youre coming off semaglutide the honest answer is start low and find out, theres no table
anyone tracked whether the GI difference held at the top doses
at 7.5 my appetite is gone entirely, did anyone go down rather than up
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is there a reason to titrate slower than the four week schedule
the trials titrated every four weeks to a target, most people here stop at whatever works
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
7.5 gang
while im here changed my mind about needing 15, i was chasing a number rather than an outcome
did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
5 was where i first noticed it properly, 2.5 did almost nothing for me
the two compounds arent interchangeable week for week even if the effect ends up similar
janoshik-a-2418.pdf
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*week 3 not week 5
folklore probably
no clean conversion
there is no clean conversion between the two, anyone giving you a ratio is guessing
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
is the sweet spot argument about effect or about side effects
is SURMOUNT-OSA the sleep apnoea one
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sorry to jump in plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific
40 units of a 10 solution is a lot of volume and i check that one twice every single time
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back after 25 months, do i restart at 2.5 or pick up near where i left off
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, for what its worth
does the appetite effect feel different or just stronger
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
ok so the 2.5 to 5 step was the roughest one for me and everything after was easier
15 is the top
update on the earlier thing at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win
is the 15 vial the common one or do people use 20
coming off semaglutide, is there a conversion or do i restart at 2.5
how long before the dual thing was noticeable to you
start low anyway
did anyone go past 15 and was there any point to it
im at 15 and thinking about 2, did anyone gain anything from that step
[edited]is 7.5 really the sweet spot or is that just channel folklore
the GI difference held for me right up to 15, which isnt what a couple of people here found
anyone got a 8 recon they like for the 15 vials
GIP plus GLP-1
21:35chlorhex pinned a message
held 10 for 20 months and lost 21kg over that stretch, slow and boring and fine
whats the plateau pattern here, same as semaglutide or different
the switch felt like a step down at first and then caught up around week 32
fridge-thermometer.png
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