SURMOUNT is weight
#tirzepatide 2026-04-11
Saturday31 messages5 participantstimes are UTC
Highlights from this day
- same_chromato — switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it 04:12
- same_chromato — if youre coming off semaglutide the honest answer is start low and find out, theres no table, take that with a pinch of salt 05:02
- panel_before_after — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 08:02
- gip_glp_gil — whats the plateau pattern here, same as semaglutide or different 08:11
i argued the sweet spot was nonsense and then spent 16 months at 7.5 not needing more
🙏6🎉1📈5
switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from, ymmv
im at 2 and thinking about 1, did anyone gain anything from that step
titrate slow
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
if youre coming off semaglutide the honest answer is start low and find out, theres no table, take that with a pinch of salt
🙏14📈9
changed my mind about needing 15, i was chasing a number rather than an outcome
🤝2
5 did nothing
does the appetite effect feel different or just stronger
no clean conversion
restarted at 2.5 after 24 months off and the first two doses reminded me why titration exists
7.5 gang
coming back to this why does everyone talk about 7.5 and not 10
🙏6
switched last year
start low anyway
5 was where i first noticed it properly, 2.5 did almost nothing for me
folklore probably
10 was enough
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
😂4🎉3🔥14
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
[edited]the 2 vial in 3ml gives 2.5mg/ml which puts 15 on 5 units, nice round numbers
whats the plateau pattern here, same as semaglutide or different
😂8🧊7
is the sweet spot argument about effect or about side effects
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
at 15 the GI came back for me, so my easier profile claim only applies below that
checked the units twice
is there a reason to titrate slower than the four week schedule
easier gi for me
🤝11👍4