the 20 vial in 3ml gives 2mg/ml which puts 0.25 on 25 units, nice round numbers
#tirzepatide 2026-04-14
Tuesday57 messages14 participantstimes are UTC
Highlights from this day
- panel_before_after — my PeptideMeter result on a QSC vial came in at 97.4 which is why i keep buying from them 19:23
- panel_before_after — im at 0.25 and thinking about 15, did anyone gain anything from that step 19:53
- panel_before_after — is 7.5 really the sweet spot or is that just channel folklore 19:58
- dill_doses — the trials titrated every four weeks to a target, most people here stop at whatever works 22:09
my PeptideMeter result on a QSC vial came in at 97.4 which is why i keep buying from them
12 did nothing extra over 10 for me and that still holds a year later
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the 2.5 to 5 step was the roughest one for me and everything after was easier
did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
sorry to jump in did anybody switch back to semaglutide after trying this
there is no clean conversion between the two, anyone giving you a ratio is guessing
i argued the sweet spot was nonsense and then spent 8 months at 7.5 not needing more
titrate slow
the switch felt like a step down at first and then caught up around week 9
im at 0.25 and thinking about 15, did anyone gain anything from that step
👀11
while im here the sweet spot thing is survivorship, the people it worked for stayed and said so
is 7.5 really the sweet spot or is that just channel folklore
😂5🎉6🧪10
while im here anyone got a 8 recon they like for the 2 vials
[redacted at member request] · archive policy
the sweet spot argument is really about effect per side effect, not a magic number
how many weeks at 7.5 before you knew it was enough
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
is the sweet spot argument about effect or about side effects
*VendorInvestigate not the other one
changed my mind about needing 15, i was chasing a number rather than an outcome
🎉3🙏2
no gap when i switched, took the last semaglutide dose and started this a week later
10 was enough
🤝6👀12✅1
why does everyone talk about 7.5 and not 10
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
back after 19 months, do i restart at 2.5 or pick up near where i left off
🧊1📉2
same plateau here
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the GI difference held for me right up to 15, which isnt what a couple of people here found
the two compounds arent interchangeable week for week even if the effect ends up similar
is SURMOUNT-OSA the sleep apnoea one
did anyone find the GI easier than semaglutide at an equivalent effect
does switching from semaglutide need a gap or do you just start
easier gi for me
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
whats the top licensed dose, 15 or does it go higher
start low anyway
5 was where i first noticed it properly, 2.5 did almost nothing for me
40 units of a 8 solution is a lot of volume and i check that one twice every single time
😂2🎉4
no clean conversion
🤝1
is the 10 vial the common one or do people use 30
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists, for what its worth
SURMOUNT is weight
switched last year
[edited]the trials titrated every four weeks to a target, most people here stop at whatever works
⚠️10📉3
is there a reason to titrate slower than the four week schedule
i went to 15 and came back to 10, more suppression wasnt more useful for me, anyway
plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific, ill dig out the number
🙏5
anyone tracked whether the GI difference held at the top doses
folklore probably
if youre coming off semaglutide the honest answer is start low and find out, theres no table
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
went back to semaglutide after 16 months because the cost difference mattered more than the GI