dual agonist, GIP as well as GLP-1, thats the whole difference in one line
#tirzepatide 2026-04-19
Sunday32 messages8 participantstimes are UTC
Highlights from this day
- blind_submit — update on the earlier thing SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 40 units of a 2.5 solution is a lot of volume… 22:46
- VialBot — Reminder for tarpit_tam: dose day is today. Set 4 days ago. 22:52
- septum_sal — is the sweet spot argument about effect or about side effects 23:07
- relabel_watch — did going from 1.7 semaglutide to 5 of this feel like a step down for anyone the 2 vial in 0.5ml gives 2mg/ml which puts 0.5 on 10 units, nice round numbers 23:14
start low anyway
folklore probably
did anybody switch back to semaglutide after trying this
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the two compounds arent interchangeable week for week even if the effect ends up similar
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
i went to 15 and came back to 10, more suppression wasnt more useful for me
the 15 vial in 2ml gives 10mg/ml which puts 5 on 5 units, nice round numbers
switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
[edited]titrate slow
there is no clean conversion between the two, anyone giving you a ratio is guessing
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
does the GIP arm actually explain the easier nausea or is that hand waving
does the appetite effect feel different or just stronger
7.5 gang
📈1
is the 30 vial the common one or do people use 5
GIP plus GLP-1
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
checked the units twice
vial-e-2205-front.png
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update on the earlier thing the switch felt like a step down at first and then caught up around week 15
update on the earlier thing SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
👀14🧪9🔥12
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
[edited]10 was enough
Reminder for tarpit_tam: dose day is today. Set 4 days ago.
for the archive i went to 15 and came back to 10, more suppression wasnt more useful for me, still working it out
5 was where i first noticed it properly, 2.5 did almost nothing for me
[edited]same plateau here
is the sweet spot argument about effect or about side effects
did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
the 2 vial in 0.5ml gives 2mg/ml which puts 0.5 on 10 units, nice round numbers
✅13⚠️6
switched last year
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
no gap when i switched, took the last semaglutide dose and started this a week later
5 did nothing