Assay note: SSA lot A-2601 reported at 98.1% of label content.
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#tirzepatide 2026-04-24
Friday64 messages12 participantstimes are UTC
Highlights from this day
update on the earlier thing SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
titrate slow
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7.5 gang
easier gi for me
12 did nothing extra over 10 for me and that still holds a year later
*that should say weekly
does the appetite effect feel different or just stronger
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
checked the units twice
same plateau here
for the archive the two compounds arent interchangeable week for week even if the effect ends up similar
is 7.5 really the sweet spot or is that just channel folklore
the GI difference held for me right up to 15, which isnt what a couple of people here found
anyone tracked whether the GI difference held at the top doses
coming off semaglutide, is there a conversion or do i restart at 2.5
i went to 15 and came back to 10, more suppression wasnt more useful for me, ymmv
the sweet spot thing is survivorship, the people it worked for stayed and said so
anyone got a 10 recon they like for the 15 vials
the 2.5 to 5 step was the roughest one for me and everything after was easier
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at 0.5 my appetite is gone entirely, did anyone go down rather than up
the sweet spot thing is survivorship, the people it worked for stayed and said so
switched last year
how did people handle the 2.5 to 5 jump
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whats the top licensed dose, 15 or does it go higher
*Janoshik not the other one
how long before the dual thing was noticeable to you
follow up anyone stopped at 10 and stayed there for months
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
went back to semaglutide after 26 months because the cost difference mattered more than the GI
SURMOUNT is weight
follow up at 15 the GI came back for me, so my easier profile claim only applies below that, we shall see
did anybody switch back to semaglutide after trying this
plateaued at 26 weeks the same way i did on semaglutide, so i doubt its compound specific
back after 13 months, do i restart at 2.5 or pick up near where i left off
the switch felt like a step down at first and then caught up around week 23
the 10 vial in 0.5ml gives 4mg/ml which puts 12 on 30 units, nice round numbers
GIP plus GLP-1
10 was enough
5 did nothing
does the GIP arm actually explain the easier nausea or is that hand waving
is there a reason to titrate slower than the four week schedule
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
is the 15 vial the common one or do people use 10
restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists, i have it written down somewhere
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5 was where i first noticed it properly, 2.5 did almost nothing for me, thats one data point
im at 10 and thinking about 5, did anyone gain anything from that step
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did anyone find the GI easier than semaglutide at an equivalent effect
40 units of a 10 solution is a lot of volume and i check that one twice every single time
switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
no clean conversion
On this day 8 years ago this channel logged 13 messages.
does switching from semaglutide need a gap or do you just start
€185 for a 40 vial is roughly what ive paid for the last year
changed my mind about needing 15, i was chasing a number rather than an outcome
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
held 10 for 17 months and lost 37kg over that stretch, slow and boring and fine, i think
is the sweet spot argument about effect or about side effects
i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more
the sweet spot argument is really about effect per side effect, not a magic number
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
*Medutest not the other one
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect