the 15 vial in 1ml gives 2.5mg/ml which puts 15 on 12 units, nice round numbers, we shall see
#tirzepatide 2026-05-13
Wednesday73 messages14 participantstimes are UTC
Highlights from this day
- lipase_lore — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 17:32
- salt_bridge — ok so restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists, from memory 20:25
- surpass_two — restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists 21:41
40 units of a 10 solution is a lot of volume and i check that one twice every single time
[edited]*that should say weekly
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
SURMOUNT is weight
i sat at 7.5 for 10 months and never needed more, which is where the folklore comes from, from memory
lot-log.csv
783 rows · not retained in the public archive
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plateaued at 33 weeks the same way i did on semaglutide, so i doubt its compound specific
start low anyway
checked the units twice
i argued the sweet spot was nonsense and then spent 15 months at 7.5 not needing more
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the switch felt like a step down at first and then caught up around week 21
no clean conversion
quick one the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
my PeptideMeter result on a TFC vial came in at 98.1 which is why i keep buying from them, ill dig out the number
at 1 my appetite is gone entirely, did anyone go down rather than up
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at 15 the GI came back for me, so my easier profile claim only applies below that
the sweet spot thing is survivorship, the people it worked for stayed and said so
titrate slow
im at 5 and thinking about 2, did anyone gain anything from that step
[edited]update on the earlier thing held 10 for 14 months and lost 17kg over that stretch, slow and boring and fine
no gap when i switched, took the last semaglutide dose and started this a week later
anyone tracked whether the GI difference held at the top doses
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why does everyone talk about 7.5 and not 10
unrelated but 12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
whats the top licensed dose, 15 or does it go higher
how many weeks at 7.5 before you knew it was enough
5 was where i first noticed it properly, 2.5 did almost nothing for me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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5 did nothing
the 2.5 to 5 step was the roughest one for me and everything after was easier
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does switching from semaglutide need a gap or do you just start
GIP plus GLP-1
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the sweet spot argument is really about effect per side effect, not a magic number
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)easier gi for me
went back to semaglutide after 13 months because the cost difference mattered more than the GI
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
[redacted at member request] · archive policy
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7.5 gang
whats the plateau pattern here, same as semaglutide or different
10 was enough
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it, take that with a pinch of salt
i went to 15 and came back to 10, more suppression wasnt more useful for me, i could be wrong
changed my mind about needing 15, i was chasing a number rather than an outcome
if youre coming off semaglutide the honest answer is start low and find out, theres no table
[edited]wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)slightly off topic but dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the GI difference held for me right up to 15, which isnt what a couple of people here found
[edited]folklore probably
how did people handle the 2.5 to 5 jump
there is no clean conversion between the two, anyone giving you a ratio is guessing
switched last year
the trials titrated every four weeks to a target, most people here stop at whatever works, i think
is the sweet spot argument about effect or about side effects
back after 9 months, do i restart at 2.5 or pick up near where i left off
the two compounds arent interchangeable week for week even if the effect ends up similar
while im here licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, still working it out
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me
ok so restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists, from memory
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for the archive 15 is the top
is the 20 vial the common one or do people use 2
GIP plus GLP-1
folklore probably
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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start low anyway
same plateau here
titrate slow
went back to semaglutide after 17 months because the cost difference mattered more than the GI
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15 is the top
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restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists
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folklore probably
7.5 gang
7.5 gang