40 units of a 5 solution is a lot of volume and i check that one twice every single time
#tirzepatide 2026-05-17
Sunday26 messages7 participantstimes are UTC
Highlights from this day
- month_six_me — if youre coming off semaglutide the honest answer is start low and find out, theres no table 12:47
- month_six_me — the 2.5 to 5 step was the roughest one for me and everything after was easier 13:48
- willow_waits — restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists at 15 the GI came back for me, so my easier profile claim only applies… 14:33
if youre coming off semaglutide the honest answer is start low and find out, theres no table
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
⚠️4
easier gi for me
folklore probably
👍1
did anyone find the GI easier than semaglutide at an equivalent effect
🤝1
plateaued at 25 weeks the same way i did on semaglutide, so i doubt its compound specific
[edited]the 2.5 to 5 step was the roughest one for me and everything after was easier
🔥15⚠️6👍8
changed my mind about needing 15, i was chasing a number rather than an outcome
is SURMOUNT-OSA the sleep apnoea one
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
is the 40 vial the common one or do people use 20
anyone got a 10 recon they like for the 5 vials
is there a reason to titrate slower than the four week schedule
restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists
at 15 the GI came back for me, so my easier profile claim only applies below that
🧪1😂10
GIP plus GLP-1
is 7.5 really the sweet spot or is that just channel folklore
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
start low anyway
the 2 vial in 5ml gives 4mg/ml which puts 2.4 on 40 units, nice round numbers
did anybody switch back to semaglutide after trying this
15 is the top
switched last year
the sweet spot argument is really about effect per side effect, not a magic number
there is no clean conversion between the two, anyone giving you a ratio is guessing
i went to 15 and came back to 10, more suppression wasnt more useful for me, still working it out
[edited]does the GIP arm actually explain the easier nausea or is that hand waving