tirz hits both the GIP and the GLP-1 receptor. sema only the GLP-1 one
Thread · #tirzepatide · 2025-05-19
why GIP might be doing the nausea favour
Spun off from a message in #tirzepatide on 2025-05-19. 10 messages, 5 participants.
The message this came from
- lean_mass_lex — side branch because we always end up here. the mechanism argument for why tirz is often easier on the stomach 21:23
there is decent preclinical work suggesting GIP receptor activity in the brainstem dampens nausea and vomiting signalling
so GIP is an anti nausea drug bolted onto a GLP-1
thats an over simplification i can live with
it also means you can push the GLP-1 side harder before the stomach objects, which may be most of the extra efficacy
may be. its an attractive story and it is not proven in humans
does that match what people here actually feel
for me yes. 15mg tirz was easier than 2.4 sema and that should not be true on GLP-1 exposure alone
same, and two people i know had it exactly the other way round. so, n of small
🙋6
which is why the honest answer is: plausible mechanism, real clinical pattern, no proof of causation. thread over