the two compounds arent interchangeable week for week even if the effect ends up similar, that was my second climb
Thread · #tirzepatide · 2026-06-02
did anyone see the appetite effect and the weight
Spun off from a message in #tirzepatide on 2026-06-02. 14 messages, 4 participants.
The message this came from
- lean_mass_lex — small correction to my earlier message did anyone see the appetite effect and the weight move at different times 21:44
the appetite effect rides the dose for me and the volume tolerance does not, which took two years to notice
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not a clinician
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, someone will correct me
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the appetite change came first and the weight followed by a few weeks, consistently, at every step, that was my ladder, not a recommendation
a plateau that broke with nothing changed is in my log three times and i have stopped trying to explain them
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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40 units of a 4 solution is a lot of volume and i check that one twice every single time
residual_solventa plateau that broke with nothing changed is in my log three times and i have stopped…
SURMOUNT-1 is the weight trial and the SURPASS programme is the glycaemic one, and people quote them across each other constantly
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not a prescriber but does the gip side actually feel different or is that suggestion, or have i misread it
trial pedantry again, sorry two years of notes and the only consistent thing is that the steps got easier as i went up, steadier through the week for me
opposite for me
the trials that pushed to the top doses were measuring what the top doses could do, not what you should take, the middle did more for me
i logged volume tolerance separately from appetite and the two moved at different times, SURMOUNT is the weight one