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#cagrilintide 2025-04-19

Saturday23 messages6 participantstimes are UTC
Highlights from this day
  • rezept_rolf — has REDEFINE reported or are people quoting earlier work 23:10
  • rezept_rolf — did the nausea feel different to you or just less 23:51
  • rezept_rolf — two Janoshik results on the same HJ lot came back 97.4 and 98.1, closer than i expected 23:58
CC

i keep the two on separate days so if something goes wrong i have a chance of knowing which

RR

i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something

amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist

has REDEFINE reported or are people quoting earlier work

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TT

the fullness effect hasnt faded over 4 months, unlike my semaglutide appetite curve, thats one data point

1📈1

back after 9 months, is monotherapy still a minority thing here

ST

combination GI was worse than either alone for me, which is not what i had read anywhere

anyone holding at 10 for a while before stepping

MM

while im here the reason nausea reads differently is timing, mine arrived on the second day rather than the first

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VO

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way, thats one data point

follow up nobody should copy my schedule, im describing it because people asked what a slow ramp looks like

VO

i titrated over twice as many weeks as i did on semaglutide and that was right for me

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amylin analogue, so its not a GLP-1 at all right

ST

slightly off topic but dosing them on different days made no difference i could detect

TT

i was sceptical about monotherapy and after 16 months im still sceptical, just less so

RR

the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
the slower titration in here is community habit as much as anything, the trials had their own schedule

TT

lost 63lb over 25 months on the combination and i genuinely cannot apportion it

amylin not glp-1

RR

two Janoshik results on the same HJ lot came back 97.4 and 98.1, closer than i expected

📉5💀18