fullness rather than nausea
#cagrilintide 2025-04-20
Sunday37 messages6 participantstimes are UTC
Highlights from this day
- private_script_pri — coming back to this the slower titration in here is community habit as much as anything, the trials had their own schedule 22:54
- cagri_curious — you cannot tell which of the two is doing what in a combination and i stopped pretending i could 22:56
- private_script_pri — does amylin do something about fullness that the GLP-1 doesnt 23:28
thats the phase 3 one
update on the earlier thing i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
does the fullness effect fade the way appetite suppression does
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
went slower because the first step gave me two rough days and i took that as information
different not less
⚠️14
separate days
monotherapy question, did appetite move for you without a GLP-1 alongside
coming back to this the slower titration in here is community habit as much as anything, the trials had their own schedule
🙏7🧪2
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
👀1⚠️13🙏2
*VendorInvestigate not the other one
is 2.4 the number for this too or am i confusing compounds
held at 1.7 for 6 months on monotherapy before i touched it again
titrating dead slow
underwhelming honestly
👍1🧪3❤️2
back after 24 months, is monotherapy still a minority thing here
noticed something around week 27 on monotherapy, well after i had given up expecting to
went slower because the first step gave me two rough days and i took that as information
held mine a while
combination for me
monotherapy here
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
Inter-lab diff for lot E-2205: 96.8% vs 98.6%. Within expected range.
$240 for a 40 vial and it lasts me longer than the GLP-1 does at my doses, ill dig out the number
amylin not glp-1
sorry to jump in REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
dosing them on different days made no difference i could detect, i have it written down somewhere
does amylin do something about fullness that the GLP-1 doesnt
❤️6✅9🙏6
did the combination change your GI compared to the GLP-1 alone
dropped the GLP-1 and stayed on this alone for 22 months, appetite held but weight barely moved
slightly off topic but the nausea felt different rather than less, more fullness and less of the queasy wave
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
added it to an existing retatrutide dose rather than starting both, which made attribution possible
added it to an existing semaglutide dose rather than starting both, which made attribution possible
weekly for me, same day every week, no reason beyond habit
the reason nausea reads differently is timing, mine arrived on the second day rather than the first, i have it written down somewhere
did anyone find monotherapy underwhelming
anyone got two VendorInvestigate results on the same QST lot for this