if the current dose is still working, going up is spending headroom you might want later
👍3👀1
#dosing-titration 2024-04-25
Thursday22 messages8 participantstimes are UTC
Highlights from this day
- VialBot — New independent result logged — GL Biochem, lot E-2205, purity 97.4% (VendorInvestigate). 20:10
- food_noise_off — ok so i hold for two months minimum before i decide a dose has stopped doing anything, happy to be corrected 20:50
- vialkeeper — small steps are better than big ones and the only reason people take big ones is impatience 22:28
the ladder in the trials is a starting point, not a schedule you owe anyone
end of week thing
the people who do best here are almost always the ones going slowest
has anyone gone up and then straight back down and been glad they tried
hold
the honest answer is that most of us are running protocols nobody has ever studied
nobody here can tell you what dose to be on and the ones who try get corrected
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i would hold
you do not have to escalate at all. that is a real option that gets forgotten
half life is a week
appetite returning at the end of the week is extremely common and is not the dose failing
update from 25 months ago: held at the same dose the whole time and still losing slowly
how much does the last dose still matter 2 days later
New independent result logged — GL Biochem, lot E-2205, purity 97.4% (VendorInvestigate).
👍1👀13
is it normal for appetite to come back at the end of the week
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
is there a point where going up stops buying you anything
*VendorInvestigate not the other one
ok so i hold for two months minimum before i decide a dose has stopped doing anything, happy to be corrected
📈10👀1📉6
my titration ladder took 26 months to climb and i would do it slower again
small steps are better than big ones and the only reason people take big ones is impatience
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if i took it 6 days late do i shift the schedule or go back to the old day