the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
#dosing-titration 2024-10-25
Friday32 messages7 participantstimes are UTC
Highlights from this day
- back_from_away — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 18:06
- invoice_mismatch — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 18:45
- invoice_mismatch — with a roughly seven day half-life you are near steady state after about five weeks at a dose 19:12
- week_zero — sorry to jump in if it "stopped working after four days" that is almost never pharmacokinetics 20:55
go slower
pick a day and stick to it
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
for the archive if i hold at 15 indefinitely am i losing anything
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
i drifted from sunday to wednesday over a year and only noticed when i checked the log
no trial for that
plateau versus set point is not answerable in under six months of data
update question: did anyone who held for 12 months regret it
the honest answer is that most of us are running protocols nobody has ever studied
if the current dose is still working, going up is spending headroom you might want later
is there a trial anywhere that studied twice weekly, or is it all anecdote
held for months
small steps are better than big ones and the only reason people take big ones is impatience
with a roughly seven day half-life you are near steady state after about five weeks at a dose
came down from a treatment dose to maintenance over about three months and it was uneventful
how much does the last dose still matter 5 days later
the ladder in the trials is a starting point, not a schedule you owe anyone
thats anecdote
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my titration ladder took 24 months to climb and i would do it slower again
coming down from 2.4 to 2, how bad is the appetite rebound
end of week thing
if you are asking whether to go up, the fact you are asking usually means not yet
i went up too fast and im paying for it, do i drop back or ride it out
if i took it 4 days late do i shift the schedule or go back to the old day
*Janoshik not the other one
sorry to jump in if it "stopped working after four days" that is almost never pharmacokinetics
half life is a week
hold
came down, no regrets
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat