is there any actual reason to escalate every 4 weeks other than the trial did it
#dosing-titration 2024-10-26
Saturday43 messages8 participantstimes are UTC
Highlights from this day
- septum_sal — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 14:11
- septum_sal — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 16:17
- rotate_the_site — the people who do best here are almost always the ones going slowest, thats just me 16:19
- rotate_the_site — appetite returning at the end of the week is extremely common and is not the dose failing 17:16
my titration ladder took 3 months to climb and i would do it slower again
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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two weeks is nothing
half life is a week
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came down, no regrets
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
thats anecdote
is there a point where going up stops buying you anything
if i took it 4 days late do i shift the schedule or go back to the old day
if it "stopped working after four days" that is almost never pharmacokinetics
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how much does the last dose still matter 8 days later
steady state is 5 weeks
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
how do you decide between holding and stepping when both feel wrong
coming down from 1.7 to 15, how bad is the appetite rebound
thats noise
slightly off topic but is there a trial anywhere that studied twice weekly, or is it all anecdote
i hold for two months minimum before i decide a dose has stopped doing anything
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update from 24 months ago: held at the same dose the whole time and still losing slowly
the honest answer is that most of us are running protocols nobody has ever studied
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whats your rule for when a side effect means hold rather than push
thats normal
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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the people who do best here are almost always the ones going slowest, thats just me
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the ladder in the trials is a starting point, not a schedule you owe anyone
holding is not failing. most people here who lasted two years held at least one dose for months
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split dosing has no trial behind it. people here do it and report on it, thats all
quick one whats the longest anyone has stayed on one dose
nobody here can tell you what dose to be on and the ones who try get corrected
[edited]held for months
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came down from a treatment dose to maintenance over about three months and it was uneventful
my dose day has drifted 2 days later over 16 months, does it matter
appetite returning at the end of the week is extremely common and is not the dose failing
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
follow up small steps are better than big ones and the only reason people take big ones is impatience
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
with a roughly seven day half-life you are near steady state after about five weeks at a dose, someone check my working
not advice
whats a sensible maintenance dose after a year at treatment dose
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