is there any actual reason to escalate every 4 weeks other than the trial did it
#dosing-titration 2024-11-03
Sunday40 messages10 participantstimes are UTC
Highlights from this day
- pooled_sample — whats your rule for when a side effect means hold rather than push i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 21:14
- nhs_pathway_nell — split dosing has no trial behind it. people here do it and report on it, thats all 21:55
- VialBot — Channel stats, last 30 days: 94 messages from 31 members. 22:37
- bolus_bo — i hold for two months minimum before i decide a dose has stopped doing anything 22:58
- bolus_bo — do you tell your prescriber you held or do you just hold 23:00
nobody here can tell you what dose to be on and the ones who try get corrected
genuine question i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
for the archive update from 3 months ago: held at the same dose the whole time and still losing slowly
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month
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how long did you hold at 7.5 before you moved up
too early imo
the trials escalated on a fixed schedule because a trial has to. you are not a trial
whats your rule for when a side effect means hold rather than push
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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stepping back down on purpose is a completely reasonable move and this channel should say so more often, for what its worth
[edited]pick a day and stick to it
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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n of 1
holding is not failing. most people here who lasted two years held at least one dose for months
slightly off topic but plateau versus set point is not answerable in under six months of data
came down, no regrets
i would hold
split dosing has no trial behind it. people here do it and report on it, thats all
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlif i took it 5 days late do i shift the schedule or go back to the old day
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thats normal
end of week thing
you do not have to escalate at all. that is a real option that gets forgotten
not advice
steady state is 5 weeks
is there a point where going up stops buying you anything
i drifted from sunday to wednesday over a year and only noticed when i checked the log, we shall see
[edited]Channel stats, last 30 days: 94 messages from 31 members.
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sorry to jump in appetite returning at the end of the week is extremely common and is not the dose failing
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thats anecdote
the ladder in the trials is a starting point, not a schedule you owe anyone
i hold for two months minimum before i decide a dose has stopped doing anything
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do you tell your prescriber you held or do you just hold
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follow up is week 18 too early to be thinking about the next step
hold
anyone tracked whether a smaller more frequent dose changed their side effects
is there a trial anywhere that studied twice weekly, or is it all anecdote
whats a sensible maintenance dose after a year at treatment dose
the people who do best here are almost always the ones going slowest
slightly off topic but a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
janoshik-b-0114.pdf
2 pages · 791 KB · not retained in the public archive