came down from a treatment dose to maintenance over about three months and it was uneventful
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#dosing-titration 2024-11-04
Monday38 messages7 participantstimes are UTC
Highlights from this day
- area_percent — came down from a treatment dose to maintenance over about three months and it was uneventful 07:04
- assay_not_purity — is it normal for appetite to come back at the end of the week 07:36
- slow.taper — whats your rule for when a side effect means hold rather than push 11:36
- luerlok — the ladder in the trials is a starting point, not a schedule you owe anyone 11:42
right so i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
update question: did anyone who held for 7 months regret it
is it normal for appetite to come back at the end of the week
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end of week thing
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is there a trial anywhere that studied twice weekly, or is it all anecdote
for the archive do you count from injection day or from when you actually felt it
with a roughly seven day half-life you are near steady state after about five weeks at a dose
the trials escalated on a fixed schedule because a trial has to. you are not a trial
go slower
transit-times.csv
927 rows · not retained in the public archive
unrelated but does a missed week reset anything or do you just carry on
thats normal
update on the earlier thing i drifted from sunday to wednesday over a year and only noticed when i checked the log, ill dig out the number
is week 23 too early to be thinking about the next step
held for months
if you are asking whether to go up, the fact you are asking usually means not yet
while im here a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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came down, no regrets
too early imo
not advice
how much does the last dose still matter 3 days later
my titration ladder took 24 months to climb and i would do it slower again
thats anecdote
[edited]split dosing has no trial behind it. people here do it and report on it, thats all
i escalate on symptoms. if the current dose is still doing something i stay on it
hold
whats your rule for when a side effect means hold rather than push
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nobody here can tell you what dose to be on and the ones who try get corrected
the ladder in the trials is a starting point, not a schedule you owe anyone
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i went from 2 to 1 and honestly could not tell the difference in appetite
steady state is 5 weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
unrelated but do you escalate on the calendar or on how you feel
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if the current dose is still working, going up is spending headroom you might want later
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat