is there a trial anywhere that studied twice weekly, or is it all anecdote
#dosing-titration 2024-11-15
Friday40 messages8 participantstimes are UTC
Highlights from this day
- retention_time — update from 21 months ago: held at the same dose the whole time and still losing slowly 07:37
- swirl_not_shake — is it normal for appetite to come back at the end of the week 08:27
- swirl_not_shake — update question: did anyone who held for 18 months regret it 08:36
- VialBot — Reminder set. I will post here in 5 days. 10:21
came down from a treatment dose to maintenance over about three months and it was uneventful, i could be wrong
if you are asking whether to go up, the fact you are asking usually means not yet, thats one data point
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
appetite returning at the end of the week is extremely common and is not the dose failing
update from 21 months ago: held at the same dose the whole time and still losing slowly
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i went up too fast and im paying for it, do i drop back or ride it out
if the current dose is still working, going up is spending headroom you might want later
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anyone tracked whether a smaller more frequent dose changed their side effects
not advice
the honest answer is that most of us are running protocols nobody has ever studied
i went from 7.5 to 1 and honestly could not tell the difference in appetite
Inter-lab diff for lot KP-0925: 98.1% vs 99.2%. Within expected range.
is it normal for appetite to come back at the end of the week
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the people who do best here are almost always the ones going slowest
nobody here can tell you what dose to be on and the ones who try get corrected
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, for what its worth
what does the room think about jumping a rung to catch up
update question: did anyone who held for 18 months regret it
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is week 21 too early to be thinking about the next step
[edited]stepping back down on purpose is a completely reasonable move and this channel should say so more often
plateau versus set point is not answerable in under six months of data, your mileage will differ
i hold for two months minimum before i decide a dose has stopped doing anything
stepping back down on purpose is a completely reasonable move and this channel should say so more often
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
Reminder set. I will post here in 5 days.
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
plateau versus set point is not answerable in under six months of data
if it "stopped working after four days" that is almost never pharmacokinetics
steady state is 5 weeks
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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do you escalate on the calendar or on how you feel
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the trials escalated on a fixed schedule because a trial has to. you are not a trial
the ladder in the trials is a starting point, not a schedule you owe anyone
Reminder set. I will post here in 5 days.
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
came down, no regrets
thats normal
pick a day and stick to it
if i hold at 1.7 indefinitely am i losing anything