how long did you hold at 2.5 before you moved up
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#dosing-titration 2024-11-24
Sunday44 messages11 participantstimes are UTC
Highlights from this day
you do not have to escalate at all. that is a real option that gets forgotten
thats anecdote
steady state is 5 weeks
how much does the last dose still matter 2 days later
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i hold for two months minimum before i decide a dose has stopped doing anything
the ladder in the trials is a starting point, not a schedule you owe anyone, happy to be corrected
the honest answer is that most of us are running protocols nobody has ever studied
holding is not failing. most people here who lasted two years held at least one dose for months, not advice obviously
if you are asking whether to go up, the fact you are asking usually means not yet
thats normal
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whats the smallest step anyone has managed between doses
update from 15 months ago: held at the same dose the whole time and still losing slowly
held for months
my titration ladder took 18 months to climb and i would do it slower again
whats a sensible maintenance dose after a year at treatment dose
[edited]hold
the people who do best here are almost always the ones going slowest
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whats your rule for when a side effect means hold rather than push
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came down, no regrets
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
Digest for the week of 2024-03-23 has been published.
if i hold at 10 indefinitely am i losing anything
do you escalate on the calendar or on how you feel
if it "stopped working after four days" that is almost never pharmacokinetics
what does the room think about jumping a rung to catch up
the trials escalated on a fixed schedule because a trial has to. you are not a trial
half life is a week
stepping back down on purpose is a completely reasonable move and this channel should say so more often
end of week thing
while im here is week 15 too early to be thinking about the next step
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, not advice obviously
i went from 15 to 0.25 and honestly could not tell the difference in appetite
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not advice
i escalate on symptoms. if the current dose is still doing something i stay on it, ymmv
coa-a-2418.pdf
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right so split dosing has no trial behind it. people here do it and report on it, thats all
i went up too fast and im paying for it, do i drop back or ride it out
if you are asking whether to go up, the fact you are asking usually means not yet
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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the honest answer is that most of us are running protocols nobody has ever studied, still working it out
[edited]i went from 12 to 2 and honestly could not tell the difference in appetite
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if the current dose is still working, going up is spending headroom you might want later, thats just me
triple_ag_tomi escalate on symptoms. if the current dose is still doing something i stay on it, ymmv
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if i took it 2 days late do i shift the schedule or go back to the old day
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, n of 1 obviously
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess