my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
#dosing-titration 2024-12-07
Saturday34 messages7 participantstimes are UTC
Highlights from this day
- point_two_five — do you count from injection day or from when you actually felt it 14:14
- two_ml_two — right so is it normal for appetite to come back at the end of the week 14:46
- two_ml_two — you do not have to escalate at all. that is a real option that gets forgotten small steps are better than big ones and the only reason people take big ones is… 14:49
- point_two_five — stepping back down on purpose is a completely reasonable move and this channel should say so more often 15:43
right so the people who do best here are almost always the ones going slowest, ymmv
do you count from injection day or from when you actually felt it
🧪11🎉9📈18
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
right so is it normal for appetite to come back at the end of the week
🧪10
you do not have to escalate at all. that is a real option that gets forgotten
small steps are better than big ones and the only reason people take big ones is impatience
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)whats the longest anyone has stayed on one dose
[edited]if i hold at 1 indefinitely am i losing anything
with a roughly seven day half-life you are near steady state after about five weeks at a dose
holding is not failing. most people here who lasted two years held at least one dose for months
anyone tracked whether a smaller more frequent dose changed their side effects
🧪1
is week 12 too early to be thinking about the next step
❤️2🙏1
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
thats anecdote
⚠️16❤️4
while im here how much does the last dose still matter 3 days later
the trials escalated on a fixed schedule because a trial has to. you are not a trial
update question: did anyone who held for 10 months regret it
📉1👀1
stepping back down on purpose is a completely reasonable move and this channel should say so more often
💀11
steady state is 5 weeks
quick one split dosing has no trial behind it. people here do it and report on it, thats all, happy to be corrected
😂5
small steps are better than big ones and the only reason people take big ones is impatience, your mileage will differ
i went up too fast and im paying for it, do i drop back or ride it out
nobody here can tell you what dose to be on and the ones who try get corrected
🧪2
too early imo
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i would hold
[edited]half life is a week
i escalate on symptoms. if the current dose is still doing something i stay on it
for the archive my dose day has drifted 2 days later over 5 months, does it matter
end of week thing
came down, no regrets
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
while im here i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the honest answer is that most of us are running protocols nobody has ever studied
whats a sensible maintenance dose after a year at treatment dose