whats your rule for when a side effect means hold rather than push
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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#dosing-titration 2024-12-15
Sunday30 messages8 participantstimes are UTC
Highlights from this day
- madrid_mg — whats your rule for when a side effect means hold rather than push dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 17:55
- sunday_shot — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 19:56
- customs_owl — coming down from 1 to 1.7, how bad is the appetite rebound 21:24
the ladder in the trials is a starting point, not a schedule you owe anyone
Reminder for madrid_mg: dose day is today. Set 7 days ago.
is there any actual reason to escalate every 4 weeks other than the trial did it
half life is a week
[edited]small steps are better than big ones and the only reason people take big ones is impatience
how much does the last dose still matter 9 days later
plateau versus set point is not answerable in under six months of data
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i escalate on symptoms. if the current dose is still doing something i stay on it
came down, no regrets
fridge-temps.csv
123 rows · not retained in the public archive
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update question: did anyone who held for 12 months regret it
i drifted from sunday to wednesday over a year and only noticed when i checked the log
whats the longest anyone has stayed on one dose
too early imo
thats normal
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, still working it out
ok so my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
[edited]after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the honest answer is that most of us are running protocols nobody has ever studied
anyone here split their weekly into two and would they do it again
coming back to this split dosing has no trial behind it. people here do it and report on it, thats all, take that with a pinch of salt
i went from 10 to 1.7 and honestly could not tell the difference in appetite
has anyone gone up and then straight back down and been glad they tried
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe trials escalated on a fixed schedule because a trial has to. you are not a trial
pick a day and stick to it
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i have been at 12 for 15 months and honestly i have stopped wanting to move
coming down from 1 to 1.7, how bad is the appetite rebound
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
thats noise