ok so does a missed week reset anything or do you just carry on
#dosing-titration 2025-01-05
Sunday23 messages6 participantstimes are UTC
Highlights from this day
- ms_ms_mira — is it normal for appetite to come back at the end of the week 21:05
- triple_ag_tom — holding is not failing. most people here who lasted two years held at least one dose for months 21:43
- triple_ag_tom — split dosing has no trial behind it. people here do it and report on it, thats all 21:47
- VialBot — Verification log updated: SSA — evidence added, status unchanged. 22:41
update on the earlier thing update from 4 months ago: held at the same dose the whole time and still losing slowly
the trials escalated on a fixed schedule because a trial has to. you are not a trial
is it normal for appetite to come back at the end of the week
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
Testing queue: 4 submissions open, 54 awaiting dispatch.
end of week thing
appetite returning at the end of the week is extremely common and is not the dose failing
update question: did anyone who held for 9 months regret it
whats the smallest step anyone has managed between doses
has anyone gone up and then straight back down and been glad they tried
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
coming back to this with a roughly seven day half-life you are near steady state after about five weeks at a dose
holding is not failing. most people here who lasted two years held at least one dose for months
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if the current dose is still working, going up is spending headroom you might want later
[edited]i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
split dosing has no trial behind it. people here do it and report on it, thats all
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
if i took it 6 days late do i shift the schedule or go back to the old day
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
if it "stopped working after four days" that is almost never pharmacokinetics
no trial for that
hold
the ladder in the trials is a starting point, not a schedule you owe anyone
Verification log updated: SSA — evidence added, status unchanged.