came down from a treatment dose to maintenance over about three months and it was uneventful
#dosing-titration 2025-01-06
Monday43 messages7 participantstimes are UTC
Highlights from this day
- same_chromato — plateau versus set point is not answerable in under six months of data 09:30
- same_chromato — sorry to jump in if it "stopped working after four days" that is almost never pharmacokinetics 10:50
- VialBot — Batch lookup KP-0925: 9 independent reports on file, earliest 2024-07-11. 12:22
- tb500_tobias — i went from 12 to 1.7 and honestly could not tell the difference in appetite 14:06
- thirty_one_g — stepping back down on purpose is a completely reasonable move and this channel should say so more often i hold for two months minimum before i decide a dose has… 14:10
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
steady state is 5 weeks
plateau versus set point is not answerable in under six months of data
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
📈1
anyone tracked whether a smaller more frequent dose changed their side effects
update from 14 months ago: held at the same dose the whole time and still losing slowly
small steps are better than big ones and the only reason people take big ones is impatience
sorry to jump in my titration ladder took 10 months to climb and i would do it slower again
thats noise
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the people who do best here are almost always the ones going slowest
⚠️2🎉8
split dosing has no trial behind it. people here do it and report on it, thats all
sorry to jump in if it "stopped working after four days" that is almost never pharmacokinetics
✅10🎉9
whats the smallest step anyone has managed between doses
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
two weeks is nothing
💀1👍16⚠️10
no trial for that
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while im here the trials escalated on a fixed schedule because a trial has to. you are not a trial
unrelated but i have been at 0.25 for 6 months and honestly i have stopped wanting to move
came down, no regrets
🎉18
how much does the last dose still matter 8 days later
too early imo
genuine question my dose day has drifted 2 days later over 1 months, does it matter
with a roughly seven day half-life you are near steady state after about five weeks at a dose
the honest answer is that most of us are running protocols nobody has ever studied
n of 1
i would hold
Batch lookup KP-0925: 9 independent reports on file, earliest 2024-07-11.
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whats your rule for when a side effect means hold rather than push
[edited]hold
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the ladder in the trials is a starting point, not a schedule you owe anyone
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
i went from 12 to 1.7 and honestly could not tell the difference in appetite
👍16
if i took it 8 days late do i shift the schedule or go back to the old day
🧪14
half life is a week
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i hold for two months minimum before i decide a dose has stopped doing anything
nobody here can tell you what dose to be on and the ones who try get corrected
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
how long did you hold at 1.7 before you moved up
how do you tell a plateau from just being at your set point
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anyone here split their weekly into two and would they do it again
[edited]held for months
how do you decide between holding and stepping when both feel wrong