dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
#dosing-titration 2025-01-09
Thursday20 messages5 participantstimes are UTC
Highlights from this day
- lipase_lore — if you are going up because the scale stalled for two weeks, wait. two weeks is noise, still working it out 16:01
- lipase_lore — stepping back down on purpose is a completely reasonable move and this channel should say so more often, anyway 16:29
- lipase_lore — if it "stopped working after four days" that is almost never pharmacokinetics 16:30
- pharmac_pen — quick one i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 16:43
- night_pin — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess stepping back down on purpose is a completely… 16:47
with a roughly seven day half-life you are near steady state after about five weeks at a dose
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, still working it out
stepping back down on purpose is a completely reasonable move and this channel should say so more often, anyway
if it "stopped working after four days" that is almost never pharmacokinetics
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update from 20 months ago: held at the same dose the whole time and still losing slowly
i escalate on symptoms. if the current dose is still doing something i stay on it
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i have been at 2.5 for 25 months and honestly i have stopped wanting to move
the ladder in the trials is a starting point, not a schedule you owe anyone
nobody here can tell you what dose to be on and the ones who try get corrected
quick one i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
slightly off topic but how do you decide between holding and stepping when both feel wrong
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
stepping back down on purpose is a completely reasonable move and this channel should say so more often
appetite returning at the end of the week is extremely common and is not the dose failing
small steps are better than big ones and the only reason people take big ones is impatience
steady state is 5 weeks
[edited]my titration ladder took 7 months to climb and i would do it slower again
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
whats the longest anyone has stayed on one dose