i went from 0.25 to 10 and honestly could not tell the difference in appetite
#dosing-titration 2025-02-19
Wednesday47 messages10 participantstimes are UTC
Highlights from this day
- VialBot — Testing queue: 2 submissions open, 52 awaiting dispatch. 07:18
- stack_sceptic — small steps are better than big ones and the only reason people take big ones is impatience i went to the top of the ladder, felt no better than two rungs down, and… 08:18
- amylin_amy — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 08:31
- nausea_window — came down from a treatment dose to maintenance over about three months and it was uneventful 11:20
- fake_tracking — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 11:27
i hold for two months minimum before i decide a dose has stopped doing anything
if you are asking whether to go up, the fact you are asking usually means not yet
*Medutest not the other one
if it "stopped working after four days" that is almost never pharmacokinetics
no trial for that
Testing queue: 2 submissions open, 52 awaiting dispatch.
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hold
if i hold at 7.5 indefinitely am i losing anything
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stepping back down on purpose is a completely reasonable move and this channel should say so more often
how long did you hold at 5 before you moved up
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if you are asking whether to go up, the fact you are asking usually means not yet, ask me again in a month
small steps are better than big ones and the only reason people take big ones is impatience
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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update on the earlier thing the trials escalated on a fixed schedule because a trial has to. you are not a trial
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, not advice obviously
anyone tracked whether a smaller more frequent dose changed their side effects
two weeks is nothing
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
🧊7⚠️9
thats noise
how do you tell a plateau from just being at your set point
unrelated but dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
sorry to jump in do you escalate on the calendar or on how you feel
not advice
my titration ladder took 14 months to climb and i would do it slower again
appetite returning at the end of the week is extremely common and is not the dose failing
half life is a week
unrelated but holding is not failing. most people here who lasted two years held at least one dose for months
the honest answer is that most of us are running protocols nobody has ever studied
*VendorInvestigate not the other one
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
Purity check: no report on file for lot G-0641. Nothing logged either way.
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my dose day has drifted 7 days later over 25 months, does it matter
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i could be wrong
came down from a treatment dose to maintenance over about three months and it was uneventful
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
i drifted from sunday to wednesday over a year and only noticed when i checked the log, for what its worth
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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what does the room think about jumping a rung to catch up
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
has anyone gone up and then straight back down and been glad they tried
split dosing has no trial behind it. people here do it and report on it, thats all
if the current dose is still working, going up is spending headroom you might want later, for what its worth
too early imo
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the ladder in the trials is a starting point, not a schedule you owe anyone
anyone here split their weekly into two and would they do it again
nobody here can tell you what dose to be on and the ones who try get corrected
i escalate on symptoms. if the current dose is still doing something i stay on it