vialroom

#dosing-titration 2025-03-01

Saturday14 messages4 participantstimes are UTC
Highlights from this day
  • chlorhex — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 19:25
  • lean_mass_lex — came down from a treatment dose to maintenance over about three months and it was uneventful 19:46
  • lean_mass_lex — quick one i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 20:51
  • lean_mass_lex — whats a sensible maintenance dose after a year at treatment dose 20:56
  • chlorhex — how do you decide between holding and stepping when both feel wrong 21:07
CH

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

LM

came down from a treatment dose to maintenance over about three months and it was uneventful

👍17
TT

plateau versus set point is not answerable in under six months of data

quick one i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

not advice

anyone here split their weekly into two and would they do it again

whats a sensible maintenance dose after a year at treatment dose

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.
⚠️101📈6
CH

if the current dose is still working, going up is spending headroom you might want later

how long did you hold at 2 before you moved up

what does the room think about jumping a rung to catch up

CH

how do you decide between holding and stepping when both feel wrong

📈8