came down from a treatment dose to maintenance over about three months and it was uneventful
#dosing-titration 2025-03-11
Tuesday35 messages7 participantstimes are UTC
Highlights from this day
- sgp_subq — my titration ladder took 7 months to climb and i would do it slower again 18:52
- month_six_me — the ladder in the trials is a starting point, not a schedule you owe anyone 19:31
- plus_sixteen — update on the earlier thing small steps are better than big ones and the only reason people take big ones is impatience 20:01
- stack_sceptic — is there any actual reason to escalate every 4 weeks other than the trial did it 20:15
quick one i escalate on symptoms. if the current dose is still doing something i stay on it
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
holding is not failing. most people here who lasted two years held at least one dose for months
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
my titration ladder took 7 months to climb and i would do it slower again
📈9
coming down from 2.4 to 2, how bad is the appetite rebound
[edited]plateau versus set point is not answerable in under six months of data
if i took it 7 days late do i shift the schedule or go back to the old day
half life is a week
appetite returning at the end of the week is extremely common and is not the dose failing
the ladder in the trials is a starting point, not a schedule you owe anyone
🤝7😂14
how long did you hold at 2.5 before you moved up
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
n of 1
if i hold at 7.5 indefinitely am i losing anything
🎉2
update on the earlier thing small steps are better than big ones and the only reason people take big ones is impatience
👀16
slightly off topic but after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
update question: did anyone who held for 19 months regret it
how do you decide between holding and stepping when both feel wrong
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i went up too fast and im paying for it, do i drop back or ride it out
coming back to this my dose day has drifted 5 days later over 25 months, does it matter
is there any actual reason to escalate every 4 weeks other than the trial did it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis there a trial anywhere that studied twice weekly, or is it all anecdote
how do you tell a plateau from just being at your set point
i hold for two months minimum before i decide a dose has stopped doing anything
the honest answer is that most of us are running protocols nobody has ever studied
i went from 10 to 2.4 and honestly could not tell the difference in appetite
if the current dose is still working, going up is spending headroom you might want later
no trial for that
holding is not failing. most people here who lasted two years held at least one dose for months
not advice
anyone here split their weekly into two and would they do it again
pick a day and stick to it
whats the longest anyone has stayed on one dose