you do not have to escalate at all. that is a real option that gets forgotten
#dosing-titration 2025-03-28
Friday44 messages9 participantstimes are UTC
Highlights from this day
- blind_submit — with a roughly seven day half-life you are near steady state after about five weeks at a dose came down from a treatment dose to maintenance over about three months… 18:11
- VialBot — Testing queue: 3 submissions open, 74 awaiting dispatch. 18:55
- VialBot — Verification log updated: MKM — evidence added, status unchanged. 19:40
- plateau_pen — i drifted from sunday to wednesday over a year and only noticed when i checked the log 21:08
too early imo
with a roughly seven day half-life you are near steady state after about five weeks at a dose
came down from a treatment dose to maintenance over about three months and it was uneventful
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slightly off topic but i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i went from 10 to 1.7 and honestly could not tell the difference in appetite
split dosing has no trial behind it. people here do it and report on it, thats all
appetite returning at the end of the week is extremely common and is not the dose failing
Assay note: JEEP lot C-4402 reported at 99% of label content.
go slower
slightly off topic but is there any actual reason to escalate every 4 weeks other than the trial did it
if you are asking whether to go up, the fact you are asking usually means not yet
thats anecdote
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Purity check: no report on file for lot A-2601. Nothing logged either way.
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
Testing queue: 3 submissions open, 74 awaiting dispatch.
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came down from a treatment dose to maintenance over about three months and it was uneventful
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
came down from a treatment dose to maintenance over about three months and it was uneventful
follow up stepping back down on purpose is a completely reasonable move and this channel should say so more often
coming down from 15 to 1.7, how bad is the appetite rebound
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if i took it 7 days late do i shift the schedule or go back to the old day
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
follow up how do you tell a plateau from just being at your set point
plateau versus set point is not answerable in under six months of data
plateau versus set point is not answerable in under six months of data
thats normal
Verification log updated: MKM — evidence added, status unchanged.
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has anyone gone up and then straight back down and been glad they tried
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlpick a day and stick to it
coa-a-2418.pdf
1 page · 130 KB · not retained in the public archive
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
do you tell your prescriber you held or do you just hold
update from 26 months ago: held at the same dose the whole time and still losing slowly
if it "stopped working after four days" that is almost never pharmacokinetics
holding is not failing. most people here who lasted two years held at least one dose for months
coming back to this is it normal for appetite to come back at the end of the week
the honest answer is that most of us are running protocols nobody has ever studied
steady state is 5 weeks
what does the room think about jumping a rung to catch up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
anyone tracked whether a smaller more frequent dose changed their side effects
i escalate on symptoms. if the current dose is still doing something i stay on it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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half life is a week
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whats your rule for when a side effect means hold rather than push
[edited]right so do you count from injection day or from when you actually felt it
whats the longest anyone has stayed on one dose
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
[edited]