ok so if you are asking whether to go up, the fact you are asking usually means not yet
#dosing-titration 2025-04-18
Friday21 messages6 participantstimes are UTC
Highlights from this day
- month_six_me — with a roughly seven day half-life you are near steady state after about five weeks at a dose 18:28
- per_mg_pete — stepping back down on purpose is a completely reasonable move and this channel should say so more often 19:07
- invoice_mismatch — whats your rule for when a side effect means hold rather than push 20:43
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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pick a day and stick to it
how do you tell a plateau from just being at your set point
too early imo
thats noise
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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small steps are better than big ones and the only reason people take big ones is impatience
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how do you decide between holding and stepping when both feel wrong
update from 3 months ago: held at the same dose the whole time and still losing slowly
[edited]i have been at 2.4 for 25 months and honestly i have stopped wanting to move
the ladder in the trials is a starting point, not a schedule you owe anyone
anyone here split their weekly into two and would they do it again
my titration ladder took 6 months to climb and i would do it slower again
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
whats your rule for when a side effect means hold rather than push
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is there any actual reason to escalate every 4 weeks other than the trial did it
with a roughly seven day half-life you are near steady state after about five weeks at a dose
quick one the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
the trials escalated on a fixed schedule because a trial has to. you are not a trial
split dosing has no trial behind it. people here do it and report on it, thats all, someone check my working
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |