hold
#dosing-titration 2025-04-19
Saturday50 messages12 participantstimes are UTC
Highlights from this day
- pbs_pip — follow up you do not have to escalate at all. that is a real option that gets forgotten 22:39
- pbs_pip — ok so my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 23:30
- sunday_shot — how do you decide between holding and stepping when both feel wrong 23:38
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if you are asking whether to go up, the fact you are asking usually means not yet
stepping back down on purpose is a completely reasonable move and this channel should say so more often
unrelated but the people who do best here are almost always the ones going slowest
slightly off topic but i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
if the current dose is still working, going up is spending headroom you might want later, happy to be corrected
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
for the archive i drifted from sunday to wednesday over a year and only noticed when i checked the log, your mileage will differ
chromatogram-overlay.png
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is there a trial anywhere that studied twice weekly, or is it all anecdote
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came down, no regrets
for the archive if i hold at 1.7 indefinitely am i losing anything
[edited]is there any actual reason to escalate every 4 weeks other than the trial did it
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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pick a day and stick to it
update from 24 months ago: held at the same dose the whole time and still losing slowly
lot-log.csv
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follow up you do not have to escalate at all. that is a real option that gets forgotten
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for the archive if it "stopped working after four days" that is almost never pharmacokinetics
[edited]nobody here can tell you what dose to be on and the ones who try get corrected
is week 22 too early to be thinking about the next step
i hold for two months minimum before i decide a dose has stopped doing anything
end of week thing
two weeks is nothing
what does the room think about jumping a rung to catch up
whats the smallest step anyone has managed between doses
appetite returning at the end of the week is extremely common and is not the dose failing
plateau versus set point is not answerable in under six months of data
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
janoshik-b-0114.pdf
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i would hold
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Digest for the week of 2025-01-08 has been published.
whats your rule for when a side effect means hold rather than push
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update question: did anyone who held for 16 months regret it
do you tell your prescriber you held or do you just hold
how much does the last dose still matter 4 days later
my dose day has drifted 8 days later over 12 months, does it matter
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, we shall see
do you escalate on the calendar or on how you feel
steady state is 5 weeks
[edited]dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
holding is not failing. most people here who lasted two years held at least one dose for months, ask me again in a month
do you count from injection day or from when you actually felt it
quick one is it normal for appetite to come back at the end of the week
appetite returning at the end of the week is extremely common and is not the dose failing
ok so my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
thats anecdote
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quick one if i took it 4 days late do i shift the schedule or go back to the old day
how do you decide between holding and stepping when both feel wrong
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n of 1
split dosing has no trial behind it. people here do it and report on it, thats all
peptidemeter-summary-b-0114.pdf
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*that should say weekly