you do not have to escalate at all. that is a real option that gets forgotten
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)❤️6🙏1📈16
#dosing-titration 2025-04-26
Saturday16 messages4 participantstimes are UTC
Highlights from this day
- provincial_pat — you do not have to escalate at all. that is a real option that gets forgotten 06:40
- seven_five_sweet — anyone here split their weekly into two and would they do it again 07:02
- provincial_pat — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 09:05
with a roughly seven day half-life you are near steady state after about five weeks at a dose
n of 1
anyone here split their weekly into two and would they do it again
🧪2
if it "stopped working after four days" that is almost never pharmacokinetics
unrelated but the people who do best here are almost always the ones going slowest
*PeptideMeter not the other one
i hold for two months minimum before i decide a dose has stopped doing anything
held for months
the ladder in the trials is a starting point, not a schedule you owe anyone
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
how much does the last dose still matter 4 days later
came down, no regrets
two weeks is nothing
appetite returning at the end of the week is extremely common and is not the dose failing
do you escalate on the calendar or on how you feel