thats normal
#dosing-titration 2025-04-27
Sunday47 messages10 participantstimes are UTC
Highlights from this day
- month_six_me — slightly off topic but came down from a treatment dose to maintenance over about three months and it was uneventful i drifted from sunday to wednesday over a year and… 20:08
- retention_time — i went up too fast and im paying for it, do i drop back or ride it out 21:52
- retention_time — the people who do best here are almost always the ones going slowest 22:22
anyone here split their weekly into two and would they do it again
if i took it 5 days late do i shift the schedule or go back to the old day
update from 9 months ago: held at the same dose the whole time and still losing slowly, ymmv
the ladder in the trials is a starting point, not a schedule you owe anyone, i have it written down somewhere
slightly off topic but came down from a treatment dose to maintenance over about three months and it was uneventful
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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genuine question if the current dose is still working, going up is spending headroom you might want later
*VendorInvestigate not the other one
whats the smallest step anyone has managed between doses
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
two weeks is nothing
if it "stopped working after four days" that is almost never pharmacokinetics
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i escalate on symptoms. if the current dose is still doing something i stay on it, not advice obviously
plateau versus set point is not answerable in under six months of data, anyway
Reminder for dark_for_ten_days: dose day is today. Set 6 days ago.
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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half life is a week
you do not have to escalate at all. that is a real option that gets forgotten, still working it out
go slower
if you are asking whether to go up, the fact you are asking usually means not yet
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is there a point where going up stops buying you anything
do you escalate on the calendar or on how you feel
steady state is 5 weeks
pick a day and stick to it
how much does the last dose still matter 8 days later
held for months
if i hold at 0.5 indefinitely am i losing anything
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not advice
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is it normal for appetite to come back at the end of the week
[edited]is week 22 too early to be thinking about the next step
i went up too fast and im paying for it, do i drop back or ride it out
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
Inter-lab diff for lot KP-0925: 99.4% vs 99%. Within expected range.
no trial for that
i would hold
appetite returning at the end of the week is extremely common and is not the dose failing
the honest answer is that most of us are running protocols nobody has ever studied
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
too early imo
stepping back down on purpose is a completely reasonable move and this channel should say so more often
whats the longest anyone has stayed on one dose
peptidemeter-summary-c-4402.pdf
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the people who do best here are almost always the ones going slowest
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hold
the trials escalated on a fixed schedule because a trial has to. you are not a trial, someone check my working
is there any actual reason to escalate every 4 weeks other than the trial did it
how long did you hold at 2 before you moved up
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it