no trial for that
#dosing-titration 2025-05-16
Friday30 messages7 participantstimes are UTC
Highlights from this day
- seven_five_sweet — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, someone check my working 17:30
- never_for_sale — i drifted from sunday to wednesday over a year and only noticed when i checked the log i went from 2.4 to 2.5 and honestly could not tell the difference in appetite 18:24
- tokyo_taper — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 18:25
- tokyo_taper — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 18:49
- bac_water_bill — whats the longest anyone has stayed on one dose 18:50
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, someone check my working
two weeks is nothing
half life is a week
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steady state is 5 weeks
follow up if the current dose is still working, going up is spending headroom you might want later
plateau versus set point is not answerable in under six months of data
coming down from 0.5 to 12, how bad is the appetite rebound
appetite returning at the end of the week is extremely common and is not the dose failing, i think
pick a day and stick to it
the ladder in the trials is a starting point, not a schedule you owe anyone, not advice obviously
i drifted from sunday to wednesday over a year and only noticed when i checked the log
i went from 2.4 to 2.5 and honestly could not tell the difference in appetite
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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i would hold
you do not have to escalate at all. that is a real option that gets forgotten
genuine question update from 21 months ago: held at the same dose the whole time and still losing slowly
n of 1
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
whats the longest anyone has stayed on one dose
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held for months
if it "stopped working after four days" that is almost never pharmacokinetics
not advice
too early imo
split dosing has no trial behind it. people here do it and report on it, thats all
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
thats noise
how do you tell a plateau from just being at your set point
do you count from injection day or from when you actually felt it
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
end of week thing