my titration ladder took 17 months to climb and i would do it slower again
#dosing-titration 2025-05-17
Saturday45 messages9 participantstimes are UTC
Highlights from this day
- ferrous_ash — you do not have to escalate at all. that is a real option that gets forgotten 09:04
- glucagon_arm — appetite returning at the end of the week is extremely common and is not the dose failing 10:04
- glucagon_arm — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, i could be wrong 10:46
- orfor_watch — nobody here can tell you what dose to be on and the ones who try get corrected, your mileage will differ 13:20
- orfor_watch — if the current dose is still working, going up is spending headroom you might want later 13:25
you do not have to escalate at all. that is a real option that gets forgotten
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how do you decide between holding and stepping when both feel wrong
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right so stepping back down on purpose is a completely reasonable move and this channel should say so more often
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i drifted from sunday to wednesday over a year and only noticed when i checked the log
coming back to this whats a sensible maintenance dose after a year at treatment dose
i hold for two months minimum before i decide a dose has stopped doing anything
half life is a week
held for months
is there any actual reason to escalate every 4 weeks other than the trial did it
appetite returning at the end of the week is extremely common and is not the dose failing
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if it "stopped working after four days" that is almost never pharmacokinetics
anyone tracked whether a smaller more frequent dose changed their side effects
steady state is 5 weeks
[edited]do you escalate on the calendar or on how you feel
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, i could be wrong
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i went from 2.4 to 10 and honestly could not tell the difference in appetite
came down from a treatment dose to maintenance over about three months and it was uneventful, we shall see
update from 6 months ago: held at the same dose the whole time and still losing slowly
coming back to this i escalate on symptoms. if the current dose is still doing something i stay on it, take that with a pinch of salt
has anyone gone up and then straight back down and been glad they tried
does a missed week reset anything or do you just carry on
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
[edited]i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, your mileage will differ
the trials escalated on a fixed schedule because a trial has to. you are not a trial
is it normal for appetite to come back at the end of the week
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whats the longest anyone has stayed on one dose
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hold
if you are asking whether to go up, the fact you are asking usually means not yet
the honest answer is that most of us are running protocols nobody has ever studied
too early imo
coming down from 1 to 0.25, how bad is the appetite rebound
small steps are better than big ones and the only reason people take big ones is impatience, happy to be corrected
nobody here can tell you what dose to be on and the ones who try get corrected, your mileage will differ
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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came down, no regrets
if the current dose is still working, going up is spending headroom you might want later
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
New independent result logged — HJ, lot B-0114, purity 96.8% (Janoshik).
New independent result logged — GGPeps, lot C-4402, purity 98.1% (Janoshik).
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thats normal
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thats anecdote
holding is not failing. most people here who lasted two years held at least one dose for months