what does the room think about jumping a rung to catch up
#dosing-titration 2025-07-06
Sunday53 messages12 participantstimes are UTC
Highlights from this day
- food_noise_off — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 17:26
- identity_shift — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, happy to be corrected 18:26
- identity_shift — i escalate on symptoms. if the current dose is still doing something i stay on it 18:40
- advance_fee_al — i have been at 2 for 9 months and honestly i have stopped wanting to move 21:51
- advance_fee_al — how do you tell a plateau from just being at your set point 21:54
whats the longest anyone has stayed on one dose
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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if it "stopped working after four days" that is almost never pharmacokinetics, anyway
too early imo
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
how much does the last dose still matter 2 days later
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follow up is week 27 too early to be thinking about the next step
pick a day and stick to it
thats normal
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if i took it 8 days late do i shift the schedule or go back to the old day
if i hold at 5 indefinitely am i losing anything
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ok so is it normal for appetite to come back at the end of the week
held for months
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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update question: did anyone who held for 17 months regret it
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right so if you are asking whether to go up, the fact you are asking usually means not yet
split dosing has no trial behind it. people here do it and report on it, thats all, i think
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thats anecdote
how long did you hold at 2.5 before you moved up
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, happy to be corrected
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i hold for two months minimum before i decide a dose has stopped doing anything
i escalate on symptoms. if the current dose is still doing something i stay on it
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)update from 3 months ago: held at the same dose the whole time and still losing slowly
unrelated but the trials escalated on a fixed schedule because a trial has to. you are not a trial
holding is not failing. most people here who lasted two years held at least one dose for months
i would hold
i went from 10 to 1.7 and honestly could not tell the difference in appetite, your mileage will differ
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, i could be wrong
not advice
do you count from injection day or from when you actually felt it
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
the honest answer is that most of us are running protocols nobody has ever studied
i went up too fast and im paying for it, do i drop back or ride it out
[edited]two_four_ceilingunrelated but the trials escalated on a fixed schedule because a trial has to. you are…
sorry to jump in stepping back down on purpose is a completely reasonable move and this channel should say so more often
two weeks is nothing
go slower
plateau versus set point is not answerable in under six months of data
no trial for that
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the ladder in the trials is a starting point, not a schedule you owe anyone
end of week thing
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coming down from 1 to 15, how bad is the appetite rebound
thats noise
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half life is a week
if the current dose is still working, going up is spending headroom you might want later
right so how do you decide between holding and stepping when both feel wrong
my titration ladder took 3 months to climb and i would do it slower again
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i have been at 2 for 9 months and honestly i have stopped wanting to move
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how do you tell a plateau from just being at your set point
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg