my titration ladder took 1 months to climb and i would do it slower again
#dosing-titration 2025-07-07
Monday28 messages6 participantstimes are UTC
Highlights from this day
- two_eight_c — with a roughly seven day half-life you are near steady state after about five weeks at a dose, take that with a pinch of salt 20:39
- lean_mass_lex — unrelated but if you are going up because the scale stalled for two weeks, wait. two weeks is noise 20:53
- kev_measures — i hold for two months minimum before i decide a dose has stopped doing anything, ill dig out the number 21:16
- kev_measures — the ladder in the trials is a starting point, not a schedule you owe anyone 21:25
is there a point where going up stops buying you anything
with a roughly seven day half-life you are near steady state after about five weeks at a dose, take that with a pinch of salt
🎉15
if i hold at 1.7 indefinitely am i losing anything
ok so appetite returning at the end of the week is extremely common and is not the dose failing
update from 16 months ago: held at the same dose the whole time and still losing slowly
go slower
unrelated but if you are going up because the scale stalled for two weeks, wait. two weeks is noise
🤝4✅1🧪2
stepping back down on purpose is a completely reasonable move and this channel should say so more often
came down, no regrets
i went up too fast and im paying for it, do i drop back or ride it out
🙏1
the people who do best here are almost always the ones going slowest
[edited]i hold for two months minimum before i decide a dose has stopped doing anything, ill dig out the number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the ladder in the trials is a starting point, not a schedule you owe anyone
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ok so how long did you hold at 15 before you moved up
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
whats a sensible maintenance dose after a year at treatment dose
if it "stopped working after four days" that is almost never pharmacokinetics
held for months
came down from a treatment dose to maintenance over about three months and it was uneventful
whats your rule for when a side effect means hold rather than push
i would hold
whats the smallest step anyone has managed between doses
steady state is 5 weeks
what does the room think about jumping a rung to catch up
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
do you tell your prescriber you held or do you just hold
you do not have to escalate at all. that is a real option that gets forgotten