#dosing-titration 2025-07-28

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
the ladder in the trials is a starting point, not a schedule you owe anyone

thats noise

thats normal

i went from 1.7 to 2.4 and honestly could not tell the difference in appetite

the honest answer is that most of us are running protocols nobody has ever studied

plateau versus set point is not answerable in under six months of data

with a roughly seven day half-life you are near steady state after about five weeks at a dose

n of 1

came down from a treatment dose to maintenance over about three months and it was uneventful, ill dig out the number
holding is not failing. most people here who lasted two years held at least one dose for months

thats anecdote

steady state is 5 weeks

if it "stopped working after four days" that is almost never pharmacokinetics, take that with a pinch of salt

if you are asking whether to go up, the fact you are asking usually means not yet

how do you tell a plateau from just being at your set point

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else