after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
#dosing-titration 2025-07-29
Tuesday31 messages5 participantstimes are UTC
Highlights from this day
- ferrous_ash — the honest answer is that most of us are running protocols nobody has ever studied my rule: if a side effect is still there at day five, i hold. if it clears by day… 19:04
- VialBot — Archive lookup: fibre_first first appears in this channel on 2024-10-08. 19:17
- evidence_or_not — if the current dose is still working, going up is spending headroom you might want later, someone check my working 19:38
do you count from injection day or from when you actually felt it
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the ladder in the trials is a starting point, not a schedule you owe anyone
the honest answer is that most of us are running protocols nobody has ever studied
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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not advice
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if you are asking whether to go up, the fact you are asking usually means not yet
whats a sensible maintenance dose after a year at treatment dose
has anyone gone up and then straight back down and been glad they tried
Archive lookup: fibre_first first appears in this channel on 2024-10-08.
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whats the longest anyone has stayed on one dose
i escalate on symptoms. if the current dose is still doing something i stay on it
*Medutest not the other one
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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if the current dose is still working, going up is spending headroom you might want later, someone check my working
i drifted from sunday to wednesday over a year and only noticed when i checked the log
is it normal for appetite to come back at the end of the week
is there a point where going up stops buying you anything
stepping back down on purpose is a completely reasonable move and this channel should say so more often
whats the smallest step anyone has managed between doses
is there any actual reason to escalate every 4 weeks other than the trial did it
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the people who do best here are almost always the ones going slowest
ok so small steps are better than big ones and the only reason people take big ones is impatience, take that with a pinch of salt
if it "stopped working after four days" that is almost never pharmacokinetics
with a roughly seven day half-life you are near steady state after about five weeks at a dose
follow up how long did you hold at 2.5 before you moved up
you do not have to escalate at all. that is a real option that gets forgotten
how much does the last dose still matter 7 days later
split dosing has no trial behind it. people here do it and report on it, thats all
go slower
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
21:47ferrous_ash pinned a message