split dosing has no trial behind it. people here do it and report on it, thats all
#dosing-titration 2025-08-01
Friday24 messages7 participantstimes are UTC
Highlights from this day
i went up too fast and im paying for it, do i drop back or ride it out
how do you tell a plateau from just being at your set point
do you tell your prescriber you held or do you just hold
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if the current dose is still working, going up is spending headroom you might want later
Assay note: CPC lot H-2814 reported at 98.6% of label content.
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
[edited]no trial for that
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is it normal for appetite to come back at the end of the week
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgif i took it 3 days late do i shift the schedule or go back to the old day
is there any actual reason to escalate every 4 weeks other than the trial did it
i hold for two months minimum before i decide a dose has stopped doing anything
update from 14 months ago: held at the same dose the whole time and still losing slowly
Verification log updated: QST — evidence added, status unchanged.
if you are asking whether to go up, the fact you are asking usually means not yet
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
unrelated but with a roughly seven day half-life you are near steady state after about five weeks at a dose
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what does the room think about jumping a rung to catch up
is there a point where going up stops buying you anything
how do you decide between holding and stepping when both feel wrong
the honest answer is that most of us are running protocols nobody has ever studied
how long did you hold at 2 before you moved up
do you escalate on the calendar or on how you feel
plateau versus set point is not answerable in under six months of data