#dosing-titration 2025-08-07

plateau versus set point is not answerable in under six months of data

whats the longest anyone has stayed on one dose

came down from a treatment dose to maintenance over about three months and it was uneventful

if it "stopped working after four days" that is almost never pharmacokinetics

how do you tell a plateau from just being at your set point
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

whats a sensible maintenance dose after a year at treatment dose
appetite returning at the end of the week is extremely common and is not the dose failing

pick a day and stick to it

the trials escalated on a fixed schedule because a trial has to. you are not a trial, i could be wrong

too early imo

you do not have to escalate at all. that is a real option that gets forgotten

half life is a week

do you escalate on the calendar or on how you feel

go slower

Reminder for half_life_hal: dose day is today. Set 9 days ago.

i drifted from sunday to wednesday over a year and only noticed when i checked the log

end of week thing

sorry to jump in if you are going up because the scale stalled for two weeks, wait. two weeks is noise

stepping back down on purpose is a completely reasonable move and this channel should say so more often

for the archive my titration ladder took 24 months to climb and i would do it slower again

how do you decide between holding and stepping when both feel wrong

how long did you hold at 1.7 before you moved up
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

slightly off topic but coming down from 2.5 to 7.5, how bad is the appetite rebound

i went from 0.25 to 15 and honestly could not tell the difference in appetite

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on